The BioSB research school builds on the bioinformatics community developed by the (former) Netherlands Bioinformatics Centre (NBIC) and the systems biology community developed by the (former) Netherlands Consortium for Systems Biology (NCSB) / Netherlands Platform for Systems Biology (SB@NL).

NBIC and NCSB were both technology centres funded by the Netherlands Genomics Initiative (NGI) who have been running national research and education programmes between 2003 and 2013. The BioSB research school capitalises on the intellectual value and expertise network developed within these programmes.