In silico life: constraint-based modelling at genome scale

Monday 09 May, 2016 - Wednesday 11 May, 2016 Vrije Universiteit Amsterdam


Constraint-based modelling is a powerful modelling methodology that is being used to model a diverse range of biological phenomena. These include both fundamental and applied questions relevant to biotechnology, microbiology and medicine. Central to constraint-based modelling is the use of a genome-scale reconstructions (GSR’s) that maps out the metabolism of a cell as a biochemical reaction network.

In this course you will be introduced to:

  • techniques for the construction of a working GSR: tools, tricks and pitfalls
  • the underlying mathematical definition and description of a constraint-based model
  • methods for interrogating models and interpreting results, such as Flux Balance Analysis and Flux Variability Analysis
  • software and standards

The preliminary course structure will be to divide each day into both lectures and practical sessions so that learned theory can immediately be applied in silico.

Target Audience

This course is primarily targeted at academic researchers such as PhD students and Postdocs in Life Sciences, Biotechnology, Bioinformatics, Biomedical Engineering, Microbiology and Systems Biology. Participants from the private sector are welcome to apply. Including both introductory and advanced components, participants would benefit from some knowledge of either biological modelling, metabolism or microbial physiology.

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